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Verapamil hydrochloride

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Purity:99.98%

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COA HPLC HNMR

Verapamil hydrochloride

Catalog No. T1010Cas No. 152-11-4

Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.

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Pack Size	Price	Availability
500 mg	$41	In Stock
1 g	$48	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
In vitro	Verapamil exhibits antiarrhythmic properties, reduces myocardial oxygen consumption in rats, and preserves Cx43 protein.
In vivo	Verapamil and Diltiazem essentially inhibit the hydrolase activity of recombinant CES2, with inhibition constants (Ki) of 0.25 ± 0.02 μM and 3.84 ± 0.99 μM, respectively.
Cell Research	Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1].
Alias	Manidon, (±)-Verapamil hydrochlorid, Verapamil HCl, Calcan hydrochloride

Chemical Properties

Molecular Weight	491.06
Formula	C27H39ClN2O4
Cas No.	152-11-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (101.82 mM)

H2O: 24.6 mg/mL (50 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0364 mL	10.1821 mL	20.3641 mL	101.8206 mL
5 mM	0.4073 mL	2.0364 mL	4.0728 mL	20.3641 mL
10 mM	0.2036 mL	1.0182 mL	2.0364 mL	10.1821 mL
20 mM	0.1018 mL	0.5091 mL	1.0182 mL	5.0910 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0407 mL	0.2036 mL	0.4073 mL	2.0364 mL
100 mM	0.0204 mL	0.1018 mL	0.2036 mL	1.0182 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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Verapamil hydrochloride

Verapamil hydrochloride